Temperature Metrology
Pharmaceutical Autoclave Temperature Validation (121C & 134C) per EN 285 & HTM 2010
📅 Published: January 7, 2027
⏱️ 8 min read
✍️ Dual Brothers Engineering
✓ ISO/IEC 17025 Compliant
Moist heat sterilization validation requires maintaining 121.0C to 124.0C for 15 minutes or 134.0C to 137.0C for 3 minutes without cold spot temperature drops.
1. Pre-Calibration and Post-Calibration Checks
Verify all multi-channel datalogging thermocouples and RTDs before and after autoclave cycles in a portable dry block calibrator like the DB Therion.
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